Saddler, the league's leading scorer at 19.8 points per game, scored 23 on 9-of-14 shooting, while Threatt had 19 points, made 7 of 13 shots and came up with six steals. Kyle Anderson added 11 points.
The Blue Hens (7-8, 2-0) pulled away with a 16-3 run early in the second half that gave them a 47-33 lead with 13:25 remaining, and they never led by fewer than 11 points the rest of the way.
Daquan Brown came off the bench to score 13 points for the Pride (4-11, 1-1), the only Hofstra player to score in double figures.
Stephen Nwaukoni had 11 rebounds for Hofstra, which beat Georgia State 52-50 Monday night to end an eight-game losing streak.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.