Oklahoma State led 36-22 at halftime and back-to-back field goals by Brown pushed the lead to 50-30 with 12:14 remaining. TCU (9-6, 0-2) got no closer than 14 the rest of the way.
The teams combined for 45 turnovers, 24 by the Cowboys, who broke a two-game losing streak.
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Florida State's student government has passed a resolution discouraging Seminoles fans from wearing Native American headdresses at games.
The second annual Gavitt Tipoff Games, eight games between members of the Big East and Big Ten to be played Nov. 14-18, will feature Villanova at Purdue in the opener.
Michael Lewis is leaving his assistant coaching job at Butler to take the same position at Nebraska under Tim Miles.