The Buffaloes (11-4, 1-2 Pac-12) ran their home record to 7-0 this season and kept the Trojans (6-10, 1-2) searching for that elusive road win. USC has now dropped 14 straight away from the Galen Center.
Eric Wise finished with 16 points for the Trojans, which haven't won on the road since Nov. 30, 2011, at UC Riverside.
Andre Roberson, one of the top rebounders in the nation, didn't start for the first time in 49 games. Colorado coach Tad Boyle declined to give a reason for Roberson's benching before the game, but said he would address the situation later.
The junior forward anxiously sat in his seat for just over four minutes, before being summoned into the game by Boyle. Roberson finished with 11 points and grabbed eight rebounds.
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Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.