Miles finished with 13 points for the Toreros (9-8, 2-0 West Coast), who snapped a six-game losing streak against San Francisco. Chris Anderson added 10 points and five assists.
San Diego hit 11 of 22 3-pointers, with most coming at key moments.
Two straight 3s by John Sinis started a 9-0 run that put the Toreros ahead 26-17. After San Diego took a 46-32 halftime lead, the Dons opened the second half on a 20-7 run to get within 53-52 on a 3-pointer by Derksen with 12:14 remaining.
Miles responded with back-to-back 3s for San Diego to build the lead back to seven, and the Toreros held on from there.
Reserve center Akolda Manyang has been charged with felony aggravated assault after being accused of punching a man in the face without provocation.
Should the 76ers take Ben Simmons No. 1? What if they get the Lakers' pick, too? And how does the rest of the top 10 shake out? Our Insiders run their latest mock draft, with Philly on the clock.
ESPN college basketball reporter Andy Katz discusses the need for the Pac-12 putting in place rules on that would prohibit storming the court after a win.