Powell, who was held scoreless in a loss at Texas A&M on Wednesday, scored the first eight points for the Razorbacks (10-5, 1-1 Southeastern Conference) on Saturday and added 6 rebounds and 6 steals.
Young added 12 of his 14 points in the second half as Arkansas bounced back from a season-worst 51-point effort in an 18-point loss against the Aggies.
Sheldon Jeter had 8 points to lead the Commodores (6-8, 0-2), who matched their season low for points and narrowly avoided setting the school mark for scoring futility. Vanderbilt committed a season-worst 26 turnovers, leading to 23 points for the Razorbacks.
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Kentucky men's basketball coach John Calipari on Thursday apologized to Rick Pitino if the Cardinals coach interpreted his recent comment about scandals on campus as directed toward Louisville.