Wyatt was 7-of-11 shooting and knocked down 3 of 4 3-pointers. Lee scored 20 points and grabbed 10 rebounds for his third double-double of the season.
The Owls (11-4, 1-1) made 47.9 percent (23 of 48) from the field and connected on 5 of 11 3-point attempts.
Rob Loe led the Billikens (12-4, 1-1) with 17 points on 7-of-11 shooting, including 3 of 4 from 3-point range. He added 11 rebounds for his first career double-double. Dwayne Evans added nine points and 13 rebounds.
Saint Louis threatened late, getting within 58-54 on Mike McCall Jr.'s free throws with 38 seconds left. Wyatt hit two foul shots on the ensuing possession, though, and after a Billiken miss, Lee added two more free throws.
After a season that saw his shooting numbers slip, should Nigel Hayes return for his senior year at Wisconsin or take the gamble to put him name in this year's NBA draft?
Isaiah Taylor talks about his decision to declare for the NBA draft and what he will miss most about Texas.
Chattanooga women's basketball coach Jim Foster has received a one-year contract extension, the same day the school gave the men's coach a two-year extension.