The Panthers (6-11, 1/3 Southwestern Athletic), who ended a six-game losing streak, never trailed after Eleby's jumper gave them an 8-7 lead 4:46 into the game.
Bryant Purvis had 20 points and 11 rebounds for the Tigers (0-14, 0-5), who have lost 24 of their last 25 games dating to last season.
Prairie View A&M led 44-36 when it went on an 11-1 run over the next 3:10 to take permanent control. Blair had nine points during the surge, which ended with his layup that gave the Panthers a 55-37 cushion with 4:06 remaining.
Gonzaga center Przemek Karnowski, who missed most of last season with a back injury, says he is returning for another year.
Wisconsin forward Nigel Hayes has withdrawn from the NBA draft and will return to the Badgers for his senior season.
Recruiting reporter Jeff Borzello has gotten grilled for his selections of underachieving and overachieving college basketball programs. He joins Phil Murphy to explain his rankings.