Denver (10-7, 6-1 WAC) was 8 of 19 from beyond the arc, was a perfect 11 for 11 from the free-throw line and dished out 22 assists as a team. The Pioneers held San Jose State to just 28 percent shooting and forced 12 turnovers.
The Pioneers dominated this game from the outset and with Royce O'Neale's 3-pointer to put Denver up 3-0 just 42 seconds into the game, the Pioneers never trailed again, leading 34-18 at halftime and outscoring the Spartans 39-19 in the second half.
O'Neale finished with seven points, 10 rebounds and five assists.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.