California drew within 43-42 with 13:20 left to play on a Crabbe jumper but the Cardinal eventually rebuilt its lead to 10 points.
Gage hit one of his three 3-pointers with 7:07 remaining to play in the first half to put the Cardinal ahead.
Crabbe, the Pac-12's leading scorer, was limited to four shots in the first half.
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Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.