Anthony D'Orazio added 12 points and eight rebounds to help Lehigh (13-4, 3-0) win its fourth straight game.
The Mountain Hawks scored the first nine points of the game, and held Colgate to just 35.7 percent (10 of 28) in the first half to take a 39-26 lead into halftime.
Colgate (6-13, 0-3) trailed the entire game. The Raiders never got within single digits in the second half as the Mountain Hawks led by as many as 17 points in the period.
Though both teams shot poorly in the second half, Lehigh held a 14-3 edge from the free-throw line after the break.
Brandon James led Colgate with 12 points and eight rebounds, but was the only player in double figures.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.