Illinois (15-5, 2-4 Big Ten) held Nebraska without a field goal for the last 8:51 of the first half and led 35-23 at the break. The Huskers got no closer than six points the rest of the way.
John Groce, in his first year at Illinois, recorded his 100th win in five seasons as a head coach.
The Illini shot 45 percent and committed 14 turnovers, but they had more offensive rebounds (12) than Nebraska had total rebounds (10) in the first half and finished with a 40-28 advantage on the boards.
Nebraska was 2 of 14 on 3s and shot 32 percent for the game.
Maryland point guard Melo Trimble has withdrawn from the NBA draft and will return to College Park for his junior season, sources told ESPN.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.