The Flames (12-8, 3-4 Horizon League) did not allow a point in the last 9:39 and outscored the Mustangs 35-8 in the second half.
Paris Gulley scored 14 points and Jordan Aaron 13 for Milwaukee (5-15, 1-5), who shot just 3 of 25 (12 percent) from the floor in the second half. They missed their last 12 shots -- all behind the 3-point arc -- and had six turnovers during the scoreless stretch.
For the game, Milwaukee was 8 for 35 (22.9 percent) from 3-point range and 18 of 56 (32.1 percent) overall.
Talton's 3-pointer put Illinois-Chicago ahead for good, 52-50, with 1:35 remaining.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.