Tony Johnson added 15 points and went 6 of 6 from the stripe for Lafayette, which made 10 of 11 free throws.
Lafayette (9-12, 2-2) scored 12 of the game's first 14 points but led by just three, 23-20, at intermission after Holy Cross' Phil Beans hit a 3-pointer as time expired. Holy Cross (10-9, 2-2), however, would get no closer as Johnson opened the second half with a layup and Hinrichs hit back-to-back 3-pointers to push Lafayette's lead to 31-20.
Dave Dudzinski knocked down a 3-pointer to cut the deficit to 36-30 but the Leopards rattled off 11 straight points to take their largest lead of the game, 47-30.
Beans had 14 points for Holy Cross and Dudzinski added 13.
Leaving early for the NBA is a risky decision. Some players -- Skal Labissiere, Dejounte Murray -- slid in the draft. Some -- Isaiah Taylor, Troy Williams -- weren't drafted at all.
College basketball coaches across the country will hit the recruiting trail hard in July to target the Class of 2017's top prospects. Which players are the nation's top programs targeting?
The Tar Heels could lose Justin Jackson and Kennedy Meeks after next season. Coach Roy Williams has nearly every top-10 2017 prospect on his board.