Jerran Young came off the bench to score 18 points for Wright State (14-6, 5-2), which had won six of its past seven games coming in. The Raiders had won nine of the past 10 games in the series.
The Penguins' previous victory over the Raiders came on Feb. 23, 2007.
Youngstown State shot 24 of 48 from the field to Wright State's 25 of 63 and made 15 of 19 from the line to the Raiders' 5 of 10.
The Penguins led 28-25 at the half and 43-33 with 13:07 to go. Wright State closed to 46-42 at 6:51, but that was as close as they got.
Charles Matthews, who spent his freshman season at Kentucky, has picked Michigan as his transfer school, according to a source.
Chad Ford and Jeff Goodman offer their opinions on the surprises they're expecting at the NBA draft, with Ford believing there will be a lot of trade activity while Goodman thinks people will be surprised by potential draft spot of Marquese Chriss.
Louisville coach Rick Pitino said he doesn't "have time to figure out what" Kentucky coach John Calipari meant in recent comments that appeared to be a jab at the Cardinals' program.