Jerran Young came off the bench to score 18 points for Wright State (14-6, 5-2), which had won six of its past seven games coming in. The Raiders had won nine of the past 10 games in the series.
The Penguins' previous victory over the Raiders came on Feb. 23, 2007.
Youngstown State shot 24 of 48 from the field to Wright State's 25 of 63 and made 15 of 19 from the line to the Raiders' 5 of 10.
The Penguins led 28-25 at the half and 43-33 with 13:07 to go. Wright State closed to 46-42 at 6:51, but that was as close as they got.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.