Purdue never trailed in overtime. Ronnie Johnson scored the go-ahead basket with 1:27 left in overtime to give Purdue a 61-59 lead. The Hawkeyes missed two free throws and two field goals and Byrd extended the lead with two free throws with 30 seconds left to make it 63-59.
The two teams meet again on Feb. 27 in Iowa City.
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Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.