LOS ANGELES -- UCLA had its chances. The Bruins couldn't get defensive stops or make shots when they needed.
"I'm a little disappointed at our effort coming out of the gate," Bruins guard Larry Drew II said. "I don't think guys, for whatever reason, maybe were all the way into the game on the defensive end."
Eric Wise added 12 points and 11 rebounds, J.T. Terrell and Byron Wesley each had 10 points for the USC (9-13, 4-5 Pac-12), which held the Bruins to 38 percent shooting while snapping a two-game losing streak.
The Trojans improved to 2/3 under interim coach Bob Cantu.
"With everything that has happened in the last couple of weeks, we just bonded together as a team," freshman Chass Bryan said, referring to coach Kevin O'Neill's firing. "E Wise, Jio, all of our seniors stepped up. It feels great to get our first win in five years in the new Pauley Pavilion. We are just playing as a team at the right time, counting on each other and trusting each other."
UCLA's Shabazz Muhammad scored 22 points but missed two 3-pointers in the final 1:14 of overtime while battling flu symptoms. He was given two liters of IV fluid before the game.
"He's a competitor," Travis Wear said. "He's not going to let it stop him."
The Bruins were 2 of 19 from 3-point range. They got outrebounded, 44-36.
"The guys stayed poised, they stayed committed and we told them to win on the road you have to stay focused and play through things," Cantu said. "When we needed a basket, we got it. When we had to get it inbounds, we got it in."
Wear, who returned after missing one game because of a concussion, added 16 points and Jordan Adams had 13 for the Bruins.
UCLA (16-6, 6-3) has dropped three of its last four and is in danger of slipping out of second place in the league after losing its only game this week.
"It's always worse when you lose to your rival and lose at home," coach Ben Howland said. "We've got some soul searching to do to find our way back."
The Bruins trailed by 15 points early in the second half and played from behind until Adams hit a jumper with 30 seconds left in regulation to tie the game at 65 and force overtime.
In the extra session, Adams' layup gave UCLA a 69-67 lead, its first since 6:49 of the first half. Fontan hit a 3-pointer before Muhammad's basket put UCLA back in front 71-70. Wesley answered for USC with a jumper that gave the Trojans a 72-71 lead. Travis Wear fouled Ari Stewart, who made both free throws for a 74-71 lead with 11 seconds left. Muhammad missed another 3-pointer and then Adams committed his first foul with 4 seconds left, sending Fontan to the line where he sealed the victory.
"We're really, really good at times and we can be really, really bad at times," Drew II said. "I try not to focus too much on the negatives, but in the last week we've lost more games than we've won. We have to try to change that and learn from our mistakes."
Playing in a less than full Pauley Pavilion, the Bruins moved out to a 21-15 lead to open the first of two regular-season meetings between the rivals. USC dominated the final 7:16 of the half with a 23-9 run that gave the Trojans a 38-30 halftime lead. Fuller scored 11 points in the spurt.
USC picked up where it left off to start the second half, going on a 14-7 run and getting four points each from Dewayne Dedmon and Wise to extend their lead to 52-37.
The Bruins started rallying with a 3-pointer by Muhammad and a more active defense. His basket keyed a 19-9 run during which Fontan picked up his fourth foul for the Trojans after scoring five straight points in the spurt that closed UCLA to 61-56. Muhammad had six points and Wear and Drew II had four each.
Muhammad stole the ball from Fontan and scored to draw UCLA within two. After Fontan scored, Drew II made a layup that again brought the Bruins to 65-63. After passing the ball around, they tied the game at 65 on Adams' short jumper.
Wise got called for his fourth foul going to the basket with 3 seconds left. After a timeout, Drew II dribbled up the court and launched a 3-pointer that hit the front of the rim as time expired, forcing overtime.
The Bruins wore alternate all-blue uniforms that featured solid color blocking of the team logos and a shimmery finish.
Reggie Miller had his No. 31 jersey retired at halftime. He starred for the Bruins from 1984-87, helping them win the NIT title as a sophomore. It's the second No. 31 jersey in the rafters at Pauley Pavilion. Ed O'Bannon wore the same number as the star of UCLA's 1995 national championship team.
"Let's bring back those short shorts I was wearing in that video," Miller told the crowd.
Later, he said, "I never thought something like this would happen. It's humbling."
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.