Kendrick Perry led the Penguins (13-9, 5-4) with 22 points. Kamren Belin made six 3-pointers and finished with 19 points, and Damian Eargle had 13 points, 12 rebounds and seven blocked shots for Youngstown State.
The game saw 12 lead changes but the Penguins never led by more than two points.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.