Detroit (16-8, 8-3 Horizon) shot 52.5 percent from the field and was 13 of 16 from the free-throw line but the Titans watched Milwaukee drain 10 3-pointers and outscore their bench 32-4.
Tied at 46, Ryan Haggerty hit a 3-pointer to put the Panthers on top 49-46 with 13:14 remaining in the game. Detroit regained the lead after a Ray McCallum fast break dunk to make it 50-49 and the Titans never trailed again.
James Haarsma had 26 points on 9-of-13 shooting including a perfect 7 for 7 from the line to lead Milwaukee (5-19, 1-9).
Doug Anderson and McCallum finished the night with 16 points apiece for Detroit, which has won four straight.
The second annual Gavitt Tipoff Games, eight games between members of the Big East and Big Ten to be played Nov. 14-18, will feature Villanova at Purdue in the opener.
Michael Lewis is leaving his assistant coaching job at Butler to take the same position at Nebraska under Tim Miles.
College basketball fans should be excited about next season's Jimmy V Classic, an event that will feature Duke's heralded freshman class.