The Panthers trailed 33-30 at the half and caught the Chanticleers at 39-39 2:22 into the second half. High Point took a 49-41 lead on McGaughy's jumper, but Coastal Carolina closed to 49-47 on Enanga's 3-pointer at 10:44.
Edwards' 3-pointer made it 59-51 at the 7:14 mark, and High Point held on.
High Point made 26 of 36 from the free-throw line, while Coastal Carolina made 7 of 10.
The second annual Gavitt Tipoff Games, eight games between members of the Big East and Big Ten to be played Nov. 14-18, will feature Villanova at Purdue in the opener.
Michael Lewis is leaving his assistant coaching job at Butler to take the same position at Nebraska under Tim Miles.
College basketball fans should be excited about next season's Jimmy V Classic, an event that will feature Duke's heralded freshman class.