Royce O'Neale added 11 points for the Pioneers (17-8, 13-2 Western Athletic), who have won six straight games and 13 of 14.
Denver used a 13-1 run to take control of the game with a 28-12 advantage with 2:20 remaining before halftime.
San Jose State, which trailed 28-14 at intermission, got no closer than 12 points in the second half.
The Pioneers shot 53.3 percent (24 of 45) from the floor.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.