The Raiders (10-17, 4-6), who snapped a three-game losing streak, led 38-16 with 4:04 left in the half.
Gabe Knutson and Anthony D'Orazio scored 17 points apiece and Holden Greiner had 12 for the Mountain Hawks (18-6, 8-2), whose four-game winning streak was halted. Lehigh was tied with Bucknell atop the Patriot League at 8-1, but Bucknell also lost, falling to Lafayette 63-62.
Colgate shot 38.1 percent on 3-pointers (8 of 21) to Lehigh's 16.7 percent (3 of 18), beat the Mountaineers on the boards 40-33, and the Raiders' bench outscored Lehigh's 15-2.
Lehigh tied Colgate at 56-all on a 3-pointer by D'Orazio with 3:04 left, but James Brandon made two free throws at 1:53, and Lehigh never caught up.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.