The Raiders (10-17, 4-6), who snapped a three-game losing streak, led 38-16 with 4:04 left in the half.
Gabe Knutson and Anthony D'Orazio scored 17 points apiece and Holden Greiner had 12 for the Mountain Hawks (18-6, 8-2), whose four-game winning streak was halted. Lehigh was tied with Bucknell atop the Patriot League at 8-1, but Bucknell also lost, falling to Lafayette 63-62.
Colgate shot 38.1 percent on 3-pointers (8 of 21) to Lehigh's 16.7 percent (3 of 18), beat the Mountaineers on the boards 40-33, and the Raiders' bench outscored Lehigh's 15-2.
Lehigh tied Colgate at 56-all on a 3-pointer by D'Orazio with 3:04 left, but James Brandon made two free throws at 1:53, and Lehigh never caught up.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.