The Panthers shot 56 percent from the field and made 7 of 12 3-point shots. They also hit 24 of 34 free throws.
Stacy Wilson led the Racers (18-7, 9-4) with 20 points. Dexter Fields scored 14, Isaiah Canaan had 12 points and Jeffery Moss scored 11 for Murray State, which was coming off a loss Thursday at Southern Illinois-Edwardsville.
At halftime, Eastern Illinois retired the No. 44 jersey of Henry Domercant, the school's and Ohio Valley Conference's all-time leading scorer with 2,602 points.