The Bobcats (12-13, 8-5 Northeast Conference), who had been outrebounding opponents by 9.7 per game, third best in Division I, had a 49-23 advantage on the boards against the Red Flash (3-22, 3-11) and outscored them 32-12 in the paint.
Earl Brown, who was averaging 8.5 rebounds for the Red Flash, got none.
Quinnipiac scored the game's first seven points and led 41-19 at halftime. Hearst had 14 points by halftime.
It was the fourth straight win for the Bobcats, who defeated Saint Francis 75-66 in overtime on Jan. 17.
Ollie Jackson scored 14 points for Saint Francis.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.