The Bobcats (12-13, 8-5 Northeast Conference), who had been outrebounding opponents by 9.7 per game, third best in Division I, had a 49-23 advantage on the boards against the Red Flash (3-22, 3-11) and outscored them 32-12 in the paint.
Earl Brown, who was averaging 8.5 rebounds for the Red Flash, got none.
Quinnipiac scored the game's first seven points and led 41-19 at halftime. Hearst had 14 points by halftime.
It was the fourth straight win for the Bobcats, who defeated Saint Francis 75-66 in overtime on Jan. 17.
Ollie Jackson scored 14 points for Saint Francis.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.