The Bluejays (22-6, 11-5) remained a game behind Missouri Valley Conference leader Wichita State. The last-place Salukis (11-16, 4-12) matched their school record for consecutive conference road losses with their 15th in a row since January 2012.
Doug McDermott had 10 points and seven rebounds for Creighton, which has won 73 straight at home against opponents with winning percentages of .500 or worse.
Jeff Early scored 12 points and Anthony Beane added 10 for the Salukis, who shot 35 percent but stayed close by converting Creighton's 15 turnovers into 15 points and outscoring the Bluejays 13-4 on second-chance baskets.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.