The Bluejays (22-6, 11-5) remained a game behind Missouri Valley Conference leader Wichita State. The last-place Salukis (11-16, 4-12) matched their school record for consecutive conference road losses with their 15th in a row since January 2012.
Doug McDermott had 10 points and seven rebounds for Creighton, which has won 73 straight at home against opponents with winning percentages of .500 or worse.
Jeff Early scored 12 points and Anthony Beane added 10 for the Salukis, who shot 35 percent but stayed close by converting Creighton's 15 turnovers into 15 points and outscoring the Bluejays 13-4 on second-chance baskets.
ESPN's Dan Dakich joins The Paul Finebaum Show to discuss the SEC's presence in the NBA Draft.
Ted Kapita was the top-rated recruit from West Virginia in the class of 2015 and recently played at DME Academy in Florida.
With the Suns drafting Tyler Ulis, they now have five guards on their roster who attended Kentucky.