Manhattan, of the Metro Atlantic Athletic Conference, took a 65-59 lead on Rhamel Brown's two free-throws with 3:55 left, and Buffalo scored only on Javon McCrea's jumper at 3:23 and Tony Watson II's 3-pointer with 42 seconds remaining.
Buffalo shot 21 of 38 from the field and 10 of 15 on 3-pointers to Manhattan's 21 of 50 and 5 of 11, but Manhattan made 18 of 23 free throws to Buffalo's 12 of 19 and scored 29 points off Buffalo's 24 turnovers.
Michael Alvarado contributed 11 points for Manhattan (11-16), 5-1 in its past six games.
Watson scored 24 points, McCrea had 15 with 11 rebounds and Jarryn Skeete added 11 points and 10 rebounds for Buffalo (11-16), of the Mid-American Conference, whose three-game winning streak ended.
Ben Simmons explains what he is focusing on ahead of the start of his NBA career.
After John Calipari's comments about the Louisville scandal, Rick Pitino says that Calipari should not be worried about other programs and to keep quiet unless he is praising another institution.
College basketball coaches across the country will hit the recruiting trail hard in July to target the Class of 2017's top prospects. Which players are the nation's top programs targeting?