Imes scored on a layup and two 3-pointers in the first 1:40 of the second half to give the Pride (7-22, 4-12) a 38-33 lead after they trailed 31-30 at halftime.
After an Old Dominion free throw, the Pride ran off 10 points for a 50-40 lead with 11:44 left.
Stevie Mejia added 10 points and 10 assists for Hofstra, which had lost 11 of its last 12.
The Monarchs, who shot a season-best 58.9 percent to beat UNC Wilmington on Wednesday night, managed just 37.5 percent (21 of 56) against Hofstra.
Mississippi State freshman guard Malik Newman will withdraw from the NBA draft, but sources told ESPN he might explore other opportunities besides returning to Mississippi State.
Seton Hall sophomore Isaiah Whitehead will stay in the NBA draft and not return for his junior season.
Washington State's trio of Josh Hawkinson, Conor Clifford and Ike Iroegbu have withdrawn from the NBA draft and will play their senior season with the Cougars.
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