Justan Banks had a near double-double, 10 points and nine rebounds to help Alabama A&M (10-18, 6-11 Southwestern Athletic Conference) snap a three-game skid.
The Bulldogs scored the first 11 points of the game and led at halftime 32-17.
Grambling State shot just 21.9 percent (7 of 32) in the first half.
Alabama A&M led by as many as 30 points in the second half.
The Bulldogs had the advantage inside, outrebounding the Tigers 45-30 and outscoring them 34-22 in the paint.
Nicholas West scored eight points off the bench, helping Alabama A&M lead 27-21 in bench points.
Grambling State (0-26, 0-17) did not have any players in double figures. Bryant Purvis led the Tigers in scoring with nine points.
Hal "King" Lear, a Temple basketball star during the 1950s, died Saturday at his White Plains, New York home.
Sebastien Bellin's friend Chris Young joins Ryan Smith on Outside the Lines to discuss his friend's bravery, courage and strength after surviving the Brussels bombings in March.
Andrew White III is leaving the Nebraska men's basketball team and will play elsewhere for his final college season.