Justan Banks had a near double-double, 10 points and nine rebounds to help Alabama A&M (10-18, 6-11 Southwestern Athletic Conference) snap a three-game skid.
The Bulldogs scored the first 11 points of the game and led at halftime 32-17.
Grambling State shot just 21.9 percent (7 of 32) in the first half.
Alabama A&M led by as many as 30 points in the second half.
The Bulldogs had the advantage inside, outrebounding the Tigers 45-30 and outscoring them 34-22 in the paint.
Nicholas West scored eight points off the bench, helping Alabama A&M lead 27-21 in bench points.
Grambling State (0-26, 0-17) did not have any players in double figures. Bryant Purvis led the Tigers in scoring with nine points.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.
The Central Intercollegiate Athletic Association says it won't move its headquarters, its basketball tournament or other conference championships from North Carolina, despite