Zach LeDay added 11 points for the Bulls (12-17, 3-14 Big East), who have won two straight following a 10-game losing streak.
Brock had three baskets and Toarlyn Fitzpatrick made a long-range jumper during an 11-2 surge that gave South Florida a 39-34 lead 5 minutes into the second half. Brock's layup, a 3-pointer by Rudd and a free throw from LeDay made it 47-36 with 10:10 left.
Brock converted a fast-break layup to put the Bulls ahead 53-38. Consecutive slams by Rudd made it 61-44 with 4:07 remaining.
The Huskies took their first lead of the game, at 30-28, on second-half opening baskets by R.J. Evans and Daniels.
Brock had six points to help South Florida take a 28-26 halftime lead.
The Huskies got within 25-24 with 5 minutes to go on a basket and 3-pointer by Daniels, who had 15 first-half points. Connecticut had a chance to tie it in the final minute of the half, but Omar Calhoun missed a wide-open dunk.
Connecticut, behind 24 points by Napier, won the other meeting between the teams this season, 69-64 in overtime on Feb 3.
Connecticut won their other meeting this season, 69-64 in overtime on Feb 3.
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Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.