Penn State (10-19, 2-15 Big Ten), last in the 12-team conference, scored the game's first 12 points, withstood a Northwestern surge, then pulled away in the second half. The Nittany Lions' only other conference win was at home against No. 7 Michigan on Feb. 27.
Northwestern (13-17, 4-13) has lost seven in a row.
Northwestern's Alex Marcotullio, who scored a career-high 22 points, put the Wildcats ahead 54-53 with a 3-pointer with 6:13 to play. But Penn State scored the next six points, beginning with Sasa Borovnjak's short jumper, and scored 13 of the game's last 18 points. Borovnjak had 15 points and 10 rebounds.
Reggie Hearn, who scored 11 points before fouling out with 3:07 to play, was the only other Northwestern player in double figures.
Charles Matthews, who spent his freshman season at Kentucky, has picked Michigan as his transfer school, according to a source.
Chad Ford and Jeff Goodman offer their opinions on the surprises they're expecting at the NBA draft, with Ford believing there will be a lot of trade activity while Goodman thinks people will be surprised by potential draft spot of Marquese Chriss.
Louisville coach Rick Pitino said he doesn't "have time to figure out what" Kentucky coach John Calipari meant in recent comments that appeared to be a jab at the Cardinals' program.