Cal Poly (16-12, 11-6 Big West) shot 44.7 percent from the field and was 14 of 20 from the free-throw line while forcing Cal State Fullerton to turn the ball over 15 times.
Kwame Vaughn and Alex Harris scored 22 points apiece and were a perfect 14 of 14 from the line combined for the Titans. Cal State Fullerton (14-16, 6-11) shot 48.8 percent from the field, making 20 of 41 shots including six 3-pointers.
The Mustangs wrap up the No. 3 seed in the Big West Conference tournament and will play sixth-seeded UC Davis on Thursday in Anaheim. Cal State Fullerton drops to the No. 8 seed and will play top seeded Long Beach State.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.
Clemson's Jaron Blossomgame says he is withdrawing from the NBA draft and returning to school for a final season.