Wake Forest (3-0), which is more than halfway through a season-opening five-game homestand, is unbeaten through three games for the second time in four seasons under coach Jeff Bzdelik.
Williams finished with 18 points -- 15 in the first half -- and Devin Thomas had 10 points and 11 rebounds.
Reggie Dillard scored 15 of his 20 points in the first half for Presbyterian (0-3).
Jordan Downing added 18 points. The rest of the team combined for 10 points.
Miller-McIntyre, a sophomore guard, has reached the 20-point mark in every game this season.
Williams connected on four first-half 3-pointers and another 18-foot jumper, helping the Demon Deacons to a 42-27 halftime edge.
Williams, a transfer from Robert Morris, hit 3-pointers on three consecutive possessions as the Demon Deacons stretched their edge to 21-11. He entered the game 0-for-7 from long range across the first two outings of the season.
Presbyterian had a better first-half shooting percentage than Wake Forest (39.3 percent to 38.9 percent) but was hurt by the Demon Deacons' 3-point shooting.
Wake Forest scored only two points in the game's last 6 1/2 minutes. The Demon Deacons shot 35.7 percent (20-of-56) for the game.
That was offset by a 46-29 rebounding advantage.
Presbyterian, with a starting lineup that included three freshmen, went 0-3 on a season-opening three-game road stretch.
The Blue Hose posted their only victory against an Atlantic Coast Conference team three seasons ago here against Wake Forest. With the loss, they dropped to 1-12 all-time against ACC opponents since joining the Division I level.
The 2017 recruiting class is short on point guards, with Trevon Duval leading only eight prospects from the ESPN 60 who are still available.
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With a trio a top recruits from Philadelphia, the Penn State basketball program is primed to finally turn a corner.