Wake Forest (3-0), which is more than halfway through a season-opening five-game homestand, is unbeaten through three games for the second time in four seasons under coach Jeff Bzdelik.
Williams finished with 18 points -- 15 in the first half -- and Devin Thomas had 10 points and 11 rebounds.
Reggie Dillard scored 15 of his 20 points in the first half for Presbyterian (0-3).
Jordan Downing added 18 points. The rest of the team combined for 10 points.
Miller-McIntyre, a sophomore guard, has reached the 20-point mark in every game this season.
Williams connected on four first-half 3-pointers and another 18-foot jumper, helping the Demon Deacons to a 42-27 halftime edge.
Williams, a transfer from Robert Morris, hit 3-pointers on three consecutive possessions as the Demon Deacons stretched their edge to 21-11. He entered the game 0-for-7 from long range across the first two outings of the season.
Presbyterian had a better first-half shooting percentage than Wake Forest (39.3 percent to 38.9 percent) but was hurt by the Demon Deacons' 3-point shooting.
Wake Forest scored only two points in the game's last 6 1/2 minutes. The Demon Deacons shot 35.7 percent (20-of-56) for the game.
That was offset by a 46-29 rebounding advantage.
Presbyterian, with a starting lineup that included three freshmen, went 0-3 on a season-opening three-game road stretch.
The Blue Hose posted their only victory against an Atlantic Coast Conference team three seasons ago here against Wake Forest. With the loss, they dropped to 1-12 all-time against ACC opponents since joining the Division I level.
The Cavaliers bring in a top-10 class of four incoming freshmen, so the Class of 2017 will be a small one. Coach Tony Bennett is aiming high.
College basketball coaches across the country will hit the recruiting trail hard in July to target the Class of 2017's top prospects. Which players are the nation's top programs targeting?
Wendell Carter, the No. 2-ranked player in the 2017 class, skipped a basketball event for a school play. And he's seriously considering Harvard.