Wake Forest (3-0), which is more than halfway through a season-opening five-game homestand, is unbeaten through three games for the second time in four seasons under coach Jeff Bzdelik.
Williams finished with 18 points -- 15 in the first half -- and Devin Thomas had 10 points and 11 rebounds.
Reggie Dillard scored 15 of his 20 points in the first half for Presbyterian (0-3).
Jordan Downing added 18 points. The rest of the team combined for 10 points.
Miller-McIntyre, a sophomore guard, has reached the 20-point mark in every game this season.
Williams connected on four first-half 3-pointers and another 18-foot jumper, helping the Demon Deacons to a 42-27 halftime edge.
Williams, a transfer from Robert Morris, hit 3-pointers on three consecutive possessions as the Demon Deacons stretched their edge to 21-11. He entered the game 0-for-7 from long range across the first two outings of the season.
Presbyterian had a better first-half shooting percentage than Wake Forest (39.3 percent to 38.9 percent) but was hurt by the Demon Deacons' 3-point shooting.
Wake Forest scored only two points in the game's last 6 1/2 minutes. The Demon Deacons shot 35.7 percent (20-of-56) for the game.
That was offset by a 46-29 rebounding advantage.
Presbyterian, with a starting lineup that included three freshmen, went 0-3 on a season-opening three-game road stretch.
The Blue Hose posted their only victory against an Atlantic Coast Conference team three seasons ago here against Wake Forest. With the loss, they dropped to 1-12 all-time against ACC opponents since joining the Division I level.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.