The Eagles (2-4) were trailing 8-7 when Reed fueled a 22-5 run with nine points. He also had a couple of steals and an assist as American broke the game open. Tony Wroblicky added 12 points, Darius Gardner had eight assists and Kyle Kager had seven rebounds.
Stephon Mosley came off the bench to score 12 for the Red Flash (1-6), all on 3-pointers. St. Francis shot just 31 percent -- compared to American's 54 percent -- and was out-rebounded 42-20.
American led 33-20 at the half and scored the first five points of the second half, turning that into a 14-2 run and the rout was on.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.
Mike Brey is looking at former Notre Dame players to fill two assistant jobs that have opened up with the departures of Martin Ingelsby and Anthony Solomon.
Purdue's 2016-17 prospects got a jolt Wednesday when forward Caleb Swanigan announced he will return for his sophomore season.