George Washington (9-1) trailed 41-32 with less than 14 minutes remaining but went on an 18-3 run over the next six minutes to take a 6-point lead.
Savage then scored 11 points -- seven on free throws -- over the final 6:41 to help the Colonials seal the win. Savage finished 11-for-15 from the free throw line while McDonald hit 10 of 12 free throws.
Boston (6-4) shot 6-for-10 on 3-pointers in the first half en route to a 32-24 halftime lead but shot just 39.3 percent from the field for the night. D.J. Irving led the Terriers with 23 points.
The Colonials also struggled from the field and found success from beyond the arc, shooting 39.6 percent but going 6-of-13 on 3s.
DeSean Murray, who averaged 20.2 points as a sophomore at Presbyterian, will transfer to Auburn to play for coach Bruce Pearl.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.