The Trojans (1-1), who shot 54.9 percent from the field, jumped out to an early 24-8 lead fueled by a layup and a trio of 3-pointers from Williams.
Troy surged further ahead and led by as many as 33 in the first half, coasting to a 59-27 lead at the break.
The Panthers were just 24 of 77 on field goal attempts, struggling to keep pace with the Trojan's shooting performance.
Williams hit five total 3-pointers, grabbed eight rebounds and dished out a game-high five assists. Josh Warren hauled in a game-high 11 rebounds and scored eight points.
Colorado State graduate transfer John Gillon has chosen Syracuse, giving the Orange a potential starter at point guard entering the 2016-17 season.
DeSean Murray, who averaged 20.2 points as a sophomore at Presbyterian, will transfer to Auburn to play for coach Bruce Pearl.
Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.