Jordan Heath opened with a 3-pointer and Canisius (15-7, 9-2 Metro Atlantic Athletic Conference) jumped to an 18-6 lead, and then ripped an 11-2 run to lead 29-11. Evan Conti's layup with 56 seconds to play cut the lead to nine, and Quinnipiac trailed 41-32 at halftime. Canisius shot 53.3 percent in the half to just 29.7 percent for Quinnipiac.
Quinnipiac (12-8, 7-4) scored in short bursts to close the gap to seven early in the second half, but Canisius replied with a 7-1 run for a 68-54 lead at 5:42, then held Quinnipiac at arm's length down the stretch.
Chris Perez scored 15 for Canisius and Heath grabbed 10 rebounds.
Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.