Joel Awich hit a 3-pointer to give Cal Poly (8-10, 4-1 Big West) a 58-53 lead with 3:05 remaining, but it turned out to be the last time the Mustangs scored.
However, Cal Poly limited the Titans (6-12, 1-3) to just a point in the final 3 1/2 minutes to hold on for the win. Alex Harris missed a jumper which would have tied the game with 2 seconds left for Cal State Fullerton.
Cal Poly scored 11 straight points early on, racing to a 17-5 lead. The Mustangs are off to its best Big West start in its program's 18 years as a conference member.
Michael Williams led Cal State-Fullerton with 20 points.
College basketball coaches across the country will hit the recruiting trail hard in July to target the Class of 2017's top prospects. Which players are the nation's top programs targeting?
Sport Science examines Ben Simmons' max vertical and passing ability, as well as concerns about his jump shot.
The Badgers will lose Nigel Hayes, Bronson Koenig and the rest of their senior class after next season. Securing a strong 2017 class is crucial.