Delaware (15-7, 7-0 Colonial Athletic Association) used a 21-3 run to open up a 23-6 lead midway through the first half. An 11-1 spurt, which was sparked and capped by 3-pointers from Usher, opened up a 42-18 Delaware advantage with 3:45 left in the half.
Daniel Dixon's 3-pointer cut the William and Mary (12-8, 4-3) deficit to 59-50 with 12:13 left, but Delaware scored 13 of the next 18 to push its lead to 17 and the Tribe never threatened again.
Marcus Thornton paced the Tribe with 19 points. Dixon set career-highs with 15 points and six rebounds.