Treveon Graham added 14 points for the Rams (15-4, 3-1 Atlantic 10). Reddic grabbed seven rebounds, Weber had five assists and VCU had 19 assists compared to only seven turnovers.
Tied at 16, VCU went on a 16-4 run and led 36-27 at the break. Graham and Melvin Johnson both made a 3-pointer and combined to score 12 points during the stretch.
Devin Oliver had 21 points for Dayton (13-6, 1-3) and Dyshawn Pierre had 14. Coming into the game, Dayton was averaging 12 turnovers per game but equaled that number in the first half. The Flyers ended the game with 18 turnovers.
Dayton got within 44-39 with 15:29 left, but VCU pushed its lead to 60-45 over the next 7 minutes.
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Former Kentucky guard Ed Davender, the only Wildcat with at least 1,500 points and 400 assists, has died. He was 49.
Guard Naz Mitrou-Long, whose 2015-16 season ended in December due to hip problems, has been granted a hardship waiver for the coming season, Iowa State said.
As the Sooners look to life without superstar Buddy Hield and his sidekicks, it's clear their unseasoned players will need to grow up fast.