"This was just what the doctor ordered for this team," Colorado coach Tad Boyle said. "Obviously, it's one game and we've got to move on. But I said after the UCLA game and I'll say it again today, 'Don't count this team out. These guys have toughness. They've got grit and we can win some games in this league."
Xavier Johnson and Jaron Hopkins had 10 points each for Colorado (15-4, 4-2 Pac-12), which sent Southern Cal (9-9, 0-5) to its season-high fifth consecutive loss. It is the worst start in conference play for the Trojans since opening the 2012 season with an eight-game skid.
"We had a great energy to start the game and we missed five point-blank shots in the lane in the first three, four minutes of the game," said Southern Cal coach Andy Enfield, whose team found itself down by 18 points early. "Then we turned the ball over when we had a layup. We basically missed 12 points to start the game. That enabled them to jump out on us and Colorado is an excellent team."
Omar Oraby and J.T. Terrell both had 16 points to lead the Trojans, who trail the all-time series with Colorado 5-3, including an 0-4 mark in Boulder.
Colorado was coming off Thursday's 69-56 loss to No. 25 UCLA. It was the Buffaloes' first game without Dinwiddie, who was leading the team in scoring, assists and steals when he tore his left ACL during a loss at Washington last Sunday. Colorado also lost Tre'Shaun Fletcher, a key reserve, for six to eight weeks when he went down with a knee injury in the same game as Dinwiddie.
"Spencer is a key aspect of this team," Scott said. "Without him, it was rough the first game. Tonight, it showed we came together. Tonight is a sign we can win without him and Tre'Shaun."
Younger players thrust into more prominent roles because of the injuries to Dinwiddie and Fletcher had difficulty producing in the UCLA loss. But it was a different story against the Trojans, with 11 of 12 Colorado players scoring.
"When the whole team gets in and everybody gets a piece of the victory, it's great," Booker said. "We can only feed off of this."
Trailing by 17 at halftime, Southern Cal started the second half by scoring four points, pulling within 40-27.
Colorado responded with a 9-0 run that included a highlight reel breakaway dunk by Hopkins, who moved into the starting lineup in place of Dinwiddie.
Byron Wesley hit a jumper for the Trojans to get them back within 49-29 with 15:14 left but the Buffaloes got a 3-pointer from Johnson to start another flurry, punctuated by Booker's 3-pointer that extended Colorado's lead to 59-32 with 12:41 left.
Soon after, the Buffaloes began emptying their bench and cruised to the runaway win.
Colorado raced to a 20-2 lead to start the game, spurred by a rugged defense that produced seven of the team's season-high 10 blocked shots in the first half.
Oraby briefly stalled Colorado's momentum by converting a three-point play and the Trojans managed to cut the Buffaloes' lead to 31-21 on a driving layup by Strahinj Gavrilovic. But Colorado closed the last 2:33 of the first half on 9-2 burst, including consecutive baskets by Scott and a 3-pointer by Booker that just beat the buzzer to take a 40-23 lead.
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Maryland point guard Melo Trimble, considered a lock to leave the program before struggling in the second half last season, has withdrawn from the NBA draft and will return for his junior season.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.