The Pilots (11-7, 3-3 West Coast Conference) shot 47.1 percent from the field. Kevin Bailey scored 13 points and Thomas Van Der Mars chipped in 10 with eight boards.
Portland held a 36-29 advantage at halftime, but trailed by two after Loyola Marymount (10-9, 2-5) opened the second half on an 11-2 run. Sharp responded, hitting three of his four 3-pointers to spark a 20-4 run and make it 58-44 with 8:50 remaining.
The Pilots have won three of their last four games, including an 82-73 upset of No. 22 Gonzaga on Jan. 9.
Maryland point guard Melo Trimble has withdrawn from the NBA draft and will return to College Park for his junior season, sources told ESPN.
Louisville's Chinanu Onuaku, who recently underwent a medical procedure to correct a heart rhythm issue detected during the combine, will keep his name in the NBA draft pool.
Andrew White III will return to the Nebraska men's basketball team next season after removing his name from the NBA draft.