Greene, who missed last season due to academic issues at a junior college, scored on a 1-yard plunge on the Hawkeyes' first possession, capping a 69-yard drive, and Iowa was on its way to an easy win.
The Hawkeyes overpowered the Black Bears (0-1) with 245 yards rushing, including a 19-yard TD run by Hampton on his first career carry.
Iowa led 22-3 at halftime and turned the game into a blowout in a 15-second stretch early in the fourth quarter. Paki O'Meara capped a 10-play-drive with a 1-yard run to make it 32-3, and after an interception by a Pat Angerer, Hampton scored to make it 39-3 with 14:43 left.
Hampton added a 22-yard TD run with 3:29 left, and finished with 68 yards on nine carries.
Jhamal Fluellen ran for 104 yards to lead Maine, which lost its fourth straight to a Football Bowl Subdivision team after winning at Mississippi State 9-7 in 2004. The 43-point loss was Maine's worst in seven meetings against FBS opponents.
Christensen started all 12 games in 2007 and had a tenuous hold on the No. 1 job after fall camp. Stanzi came in after Christensen threw a second-quarter interception, but Christensen bounced back in the second half, helping the Hawkeyes put the game out of reach.
Christensen was 9-of-15 for 122 yards, with one touchdown and one interception. Stanzi was 9-for-14 for 90 yards, playing most of the second quarter and re-entering the game in the fourth quarter.
Iowa's Bradley Fletcher came down with the interception off a tipped ball the first time Maine got the ball, and Christensen found Brandon Myers for a 4-yard touchdown pass to make it 14-0 with 3:37 to go the first quarter.
Christensen was 5-of-9 for 60 yards in the first half. But when he missed, he missed badly -- including an underthrow to Paul Chaney Jr. that Maine picked off at its own 3.
A.J. Edds bailed out Christensen with a safety that made it 16-0 with 12:31 to go in the second quarter, but Stanzi got the call for the rest of the half. He led the Hawkeyes to a pair of field goals to push Iowa's lead to 22-0.
Maine's Bryan Harvey hit a 40-yard field goal as half ended for the Black Bears' only points.
Adam Farkes was 9-of-22 for 83 yards and two interceptions for Maine.
Nike Men's Iowa Hawkeyes Black/Gold Team Issue Performance PoloShop
Former Blinn College coach Brad Franchione describes Panthers star Cam Newton's transformation from playing at the junior college in 2009 to playing in Super Bowl 50.
North Carolina inked the No. 34-ranked recruiting class in the 2016 cycle with one ESPN 300 (Tomon Fox) and four more four-stars. The class of 2017 is well on the way to besting the 2016 class with four ESPN Jr300 verbals less than one week after signing day with the most recent being in state receiver Ryan Jones Friday.
Oregon running back Thomas Tyner has decided to take a medical retirement after sitting out all of last season because of a shoulder injury.
It hasn't been an easy road at USC for Pat Haden, the former Trojans quarterback turned athletic director, but at 63, he's earned the right to relax.
Readers want to know about all "downer" material, Iowa cutting ties with Stanford and an inherent southern bias in recruiting rankings.
What did we learn from the Big 12 conference sessions this week? Jake Trotter sorts it out in this edition of the mailbag.
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