Cortez Gent threw a touchdown pass and caught another, and Lester Jean caught two touchdown passes for Florida Atlantic (1-1). Di'Ivory Edgecomb and Chris Bonner also scored touchdowns for Florida Atlantic.
Smith finished 21-for-34 for 325 yards.
Trailing 42-34, the Blazers were on the Owls' 28-yard line with less than a minute to play when a fourth-down pass by Webb went over the head of receiver Mike Jones. On the ensuing play, Pierre ran 73 yards for a touchdown to put an exclamation point on the Owls' victory.
Trailing 21-3, UAB got back in the game with a pair of second-quarter touchdowns. Webb hit Zach Lankford with a 20-yard touchdown pass to make it 21-10. A gaffe by Florida Atlantic on the ensuing kickoff gave UAB the ball back. The Owls allowed the kickoff to bounce behind kick returner Jeff Blanchard, and UAB's Ugonna Amarikwa pounced on the loose ball at the 28-yard line. Three plays later, Webb threw a 19-yard touchdown pass to Frantrell Forrest to close to 21-17.
Florida Atlantic answered with a 30-yard touchdown pass from Smith to Gent to stretch the lead to 28-17 at the half.
The Owls scored on their opening drive with a little trickery. Wide receiver Gent took the handoff on a reverse and tossed a 33-yard touchdown pass to Bonner in the corner of the end zone to give them a 7-0 lead. A 5-yard touchdown pass by Smith to Jean made it 14-0.
Running back Devontae Booker had 124 combined yards and a touchdown and Utah spoiled Jim Harbaugh's Michigan coaching debut, beating the Wolverines 24-17 on Thursday night.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Arizona star linebacker Scooby Wright will have an MRI after injuring his left knee in the first quarter of the Wildcats' season-opening 42-32 win over UTSA on Thursday night.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com
Trevone Boykin threw for 246 yards and a touchdown and ran for 92 yards and another score to help No. 2 TCU outlast Minnesota 23-17 on Thursday night.
All-American defensive end Shawn Oakman and safety Orion Stewart have been suspended for Baylor's season opener Friday against SMU for a violation of team rules, a school spokesman told ESPN.com.