The Bobcats (2-0), who opened with a win over Penn State, have won eight of nine dating back to last season.
Tettleton passed for 257 yards and also ran for 18 yards and a score, and Blankenship had 168 rushing yards on 27 carries.
The Aggies (1-1) trailed just 21-17 as late as the third quarter when Ohio's Matt Weller hit a 37-yard field goal that sparked 24 unanswered points for the Bobcats to put the game out of reach. Weller made 3 of 4 field goals to become the school's all-time leading scorer.
Nate Carpenter scored on a 22-yard interception return during that span.
Andrew Manley threw for 132 yards with a touchdown and an interception for the Aggies.
Texas Tech has 665 yards of total offense in its 48-45 victory over Texas.
DeAndre Washington ran for 173 yards and two touchdowns and Texas Tech overcame a breakout performance from Texas freshman tailback Chris Warren III as the Red Raiders beat the Longhorns 48-45 Th
Texas Tech outlasts Texas in a wild Thanksgiving game that included a fake kneel down for a touchdown.
The Red Raiders lined up like they would kneel the ball and run out the clock against Texas. Instead, Jakeem Grant surprised everyone, scoring from 40 yards out.
Quinton Flowers passed for three touchdowns and ran for two more as South Florida routed Central Florida 44-3 Saturday night.
South Florida defeats UCF 44-3 to drop the Golden Knights to 0-12 on the season.