The Bobcats (2-0), who opened with a win over Penn State, have won eight of nine dating back to last season.
Tettleton passed for 257 yards and also ran for 18 yards and a score, and Blankenship had 168 rushing yards on 27 carries.
The Aggies (1-1) trailed just 21-17 as late as the third quarter when Ohio's Matt Weller hit a 37-yard field goal that sparked 24 unanswered points for the Bobcats to put the game out of reach. Weller made 3 of 4 field goals to become the school's all-time leading scorer.
Nate Carpenter scored on a 22-yard interception return during that span.
Andrew Manley threw for 132 yards with a touchdown and an interception for the Aggies.
Houston could make the playoff. Or it could be eliminated from contention on Sept. 3. Such is life for a Group of 5 team hoping to crash the Power 5 party. And it all starts against Oklahoma.
The Oregon Ducks will put their new quarterbacks on display as well as give a first look at their new 4-3 defense under coordinator Brady Hoke.
With more evaluation, prospects like OLB Jaelan Phillips and others proved worthy of moving into or jumping in the player rankings.
It's no surprise that Alabama and LSU appear to be the strongest up front on defense in the SEC at this point.
In Da'Wan Hunte, Purdue features a defender who likely locked up a starting position at an opportune moment in his career.
Baylor lineman/curiosity LaQuan McGowan wants a shot at the NFL, but if that doesn't pan out he might consider the WWE as an alternative.