The Bobcats (2-0), who opened with a win over Penn State, have won eight of nine dating back to last season.
Tettleton passed for 257 yards and also ran for 18 yards and a score, and Blankenship had 168 rushing yards on 27 carries.
The Aggies (1-1) trailed just 21-17 as late as the third quarter when Ohio's Matt Weller hit a 37-yard field goal that sparked 24 unanswered points for the Bobcats to put the game out of reach. Weller made 3 of 4 field goals to become the school's all-time leading scorer.
Nate Carpenter scored on a 22-yard interception return during that span.
Andrew Manley threw for 132 yards with a touchdown and an interception for the Aggies.
Florida State coach Jimbo Fisher hopes quarterback Sean Maguire is ready to go full speed by the middle of June.
Graduate transfer quarterback Davis Webb has officially joined California, giving the Golden Bears an experienced option to replace No. 1 overall NFL draft pick Jared Goff.
First-year football coach Dino Babers, hired by former Syracuse AD Mark Coyle, is on the committee that will search for Coyle's replacement.
Hugh Freeze has some major holes to fill on offense with the departures of Laremy Tunsil and Laquon Treadwell, but there is Chady Kelly and good depth.
After transferring in from Montana State, Dakota Prukop has a checklist he's working from as he prepares to compete for the Oregon job.
The destination for Week 6 of the Big 12 Ultimate Road Trip is unanimous, as all three conference reporters would head to the Red River Rivalry.