Eastern Kentucky (2-1) outrushed Coastal Carolina 217 to 106 yards, with Matt Denham carrying 22 times for 121 yards and a touchdown. Denham, who surpassed the 2,000-yard mark for his career last week, now has 2,183 yards and 11 games of 100 or more yards.
Pryor (6-for-10) and Jared McClain (7-for-8) were a combined 13-of-18 passing for 225 yards and a touchdown. Goard caught four passes for 113 yards. The Colonels outgained Coastal Carolina 442 yards to 339.
It was the first game between the teams.