PROVIDENCE, R.I. -- Treavor Scales scored four touchdowns rushing to lead Harvard to a 45-31 victory against Brown in the 112th meeting between the Ivy League teams.
Harvard outscored Brown 21-14 in the volatile fourth quarter.
Colton Chapple passed for one touchdown and ran for another for the Crimson (2-0, 1-0), who opened their season with a 28-13 win over San Diego State in which Scales rushed for 173 yards and two touchdowns.
Scales rushed for 136 yards, and Chapple finished his night 30-for-40 with 351 yards passing. Seitu Smith II caught eight passes for 92 yards and a score.
Patrick Donnelly had a big day for Brown (1-1, 0-1), completing 27 of 40 passes for 336 yards and three touchdowns. Donnelly spread his completions among nine receivers.
Harvard, however, held Brown to 3-for-10 on third-down attempts and sacked Donnelly four times.
The Crimson hold an 80-30-2 advantage in the series.
Michigan coach Jim Harbaugh said Tuesday he has informed competing quarterbacks Jake Rudock and Shane Morris of his decision on a starter for the Wolverines' opener Thursday night at Utah.
Less than four months removed from his transfer to Florida State, Everett Golson has been named the Seminoles' starting quarterback.
After hinting at it for more than a week, LSU coach Les Miles confirmed Monday that Brandon Harris will start at quarterback in Saturday's opener against McNeese State.
USC AD Pat Haden said he had "thoughtful conversations" with medical professionals and that "a lot of careful thought was given" before deciding on a course of action for coach Steve Sarkisian.
A final decision in Ohio State's quarterback derby won't be revealed until just before the season kicks off, but Urban Meyer isn't ruling out playing both his decorated candidates.
With less than a week to go before the season opener, No. 9 Georgia finally has a starting quarterback. Coach Mark Richt announced Monday that Greyson Lambert had won the starting job.