The Panthers (0-4) were scoreless until the fourth quarter when D.J. Harris caught a 7-yard pass from Jerry Lovelocke, followed by an extra point from Chris Barrick, to put Prairie View on the scoreboard.
Prairie View, which ends its nonconference stretch, is seeing its worst start since 2002 when it was 0-6.
The Bison are ranked No. 1 in the FCS Coaches Top 25 and have won eight straight games since a loss to Youngstown State in November.