Caprio, William & Mary's third different starting quarterback this season, finished with 220 yards on 18-of-28 passing. His first touchdown pass, a 22-yarder to McBride, gave the Tribe (2-4) a 24-7 halftime lead.
Penn cut the deficit to 24-14 but Caprio's second touchdown pass, this time a 5-yarder to Sean Ballard, extended William & Mary's lead to 31-14 with 7:24 left in the third quarter.
McBride, who also hauled in seven passes in the Tribe's Sept. 22 matchup with Delaware, finished with 128 yards and has registered at least one reception of 20 yards or longer in the last six games.
Billy Ragone led Penn (1-3) with 207 yards and two touchdowns on 21-of-35 passing but was sacked four times.
SEC Network's Maria Taylor, Marcus Spears and Kevin Weidl discuss the fit for QB Brandon Allen at Jacksonville and RB Jonathan Williams at Buffalo.
SEC Network's Maria Taylor, Marcus Spears and Kevin Weidl discuss the former Mississippi State QB's potential with the Cowboys.
SEC Network's Marcus Spears and Kevin Weidl discuss the SEC players that will have the biggest overall impact in the NFL.
SEC Network's Marcus Spears and Kevin Weidl break down the best fits for offense and defense, and players with the most upside from Day 3 of the Draft.
The Browns drafted former Arizona LB Scooby Wright III in the seventh round of the NFL draft, and he celebrated by jumping into the pool fully clothed.
Oregon's Pharaoh Brown once faced amputation for a horrific leg injury. But he has come all the way back and starred in Oregon's spring game.
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