Wilson, who finished with 378 yards passing, tallied his fourth consecutive 300-yard passing game while Mellette had more than 100 receiving yards for the 18th time in his career.
Elon led 28-0 at halftime behind three passing touchdowns from Wilson, including two to Mellette, and a 48-yard run from Tracey Coppedge.
Western Carolina rallied in the second half, cutting the deficit to 35-23, but Wilson threw his fifth touchdown of the day, this time a 47-yarder to Mellette, to seal the win.
Eddie Sullivan led Western Carolina with 168 yards on 12-of-22 passing and added 76 yards rushing.
Elon has won the last six games in the series, scoring at least 26 points in each of those meetings.
A final decision in Ohio State's quarterback derby won't be revealed until just before the season kicks off, but Urban Meyer isn't ruling out playing both his decorated candidates.
Sales of beer with Joe Paterno's name on it are so brisk that the company that makes it is gearing up for a second run after just a week on the shelves.
Baylor coach Art Briles said Monday his fourth-ranked Bears have not been distracted by the swirling controversy surrounding the program's handling of former defensive end Sam Ukwuachu.
Junior transfer Chad Kelly, the nephew of NFL Hall of Famer Jim Kelly, will start at quarterback for Ole Miss in the Rebels' opener against Tennessee Martin on Saturday.
Florida linebacker Antonio Morrison, who injured his left knee in January and needed two surgeries to repair the damage, will play in Saturday's opener against New Mexico State.
Middle Tennessee coach Rick Stockstill has named his son, redshirt freshman Brent Stockstill, his starting quarterback for the Blue Raiders' season opener against Jackson State.