Wilson, who finished with 378 yards passing, tallied his fourth consecutive 300-yard passing game while Mellette had more than 100 receiving yards for the 18th time in his career.
Elon led 28-0 at halftime behind three passing touchdowns from Wilson, including two to Mellette, and a 48-yard run from Tracey Coppedge.
Western Carolina rallied in the second half, cutting the deficit to 35-23, but Wilson threw his fifth touchdown of the day, this time a 47-yarder to Mellette, to seal the win.
Eddie Sullivan led Western Carolina with 168 yards on 12-of-22 passing and added 76 yards rushing.
Elon has won the last six games in the series, scoring at least 26 points in each of those meetings.
Michigan coach Jim Harbaugh says young players at his camps this summer have him convinced that football has a bright future.
GameDay 100: During the Chick-fil-A Bowl in 2013, Texas A&M quarterback Johnny Manziel manages to stay on his feet, scrambling to buy time to complete the touchdown against Duke.
In the dog days of summer, some of the world's most popular sports figures take a crack at sports other than their own.
Kansas State will add experienced safety Dante Barnett to what it appears to be a very solid returning core in the secondary.
On a defense in desperate need of new playmakers, Mondeaux is one of the Ducks' and new DC Brady Hoke's best bets.
Former NFL executive and player Merton Hanks has been named senior associate commissioner of Conference USA. He will be responsible for managing the league's operations for football and baseball.
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