Wilson, who finished with 378 yards passing, tallied his fourth consecutive 300-yard passing game while Mellette had more than 100 receiving yards for the 18th time in his career.
Elon led 28-0 at halftime behind three passing touchdowns from Wilson, including two to Mellette, and a 48-yard run from Tracey Coppedge.
Western Carolina rallied in the second half, cutting the deficit to 35-23, but Wilson threw his fifth touchdown of the day, this time a 47-yarder to Mellette, to seal the win.
Eddie Sullivan led Western Carolina with 168 yards on 12-of-22 passing and added 76 yards rushing.
Elon has won the last six games in the series, scoring at least 26 points in each of those meetings.
Paul Finebaum talks about how concerned coach Hugh Freeze should be after Laremy Tunsil admitted to receiving money from an Ole Miss coach.
SEC Network highlights Gator student-athletes graduating this weekend, including gymnast Bridget Sloan and linebacker Jelani Jenkins.
SEC Network's Marcus Spears and Kevin Weidl break down the best fit, top value and Saturday sleeper after Day 2 of the 2016 NFL Draft.
Former Auburn OT Shon Coleman, who was diagnosed with leukemia in 2010, speaks at St. Jude Children's Research Hospital about being drafted by the Browns.
Former Florida DE Jonathan Bullard discusses reaching his dream of being drafted as he was selected in Round 3 by the Chicago Bears.
SEC Network's Marcus Spears and Kevin Weidl react to the Tide players taken on Day 2 of the NFL Draft and predict what's in store for Henry and Ragland.
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