Wilson, who finished with 378 yards passing, tallied his fourth consecutive 300-yard passing game while Mellette had more than 100 receiving yards for the 18th time in his career.
Elon led 28-0 at halftime behind three passing touchdowns from Wilson, including two to Mellette, and a 48-yard run from Tracey Coppedge.
Western Carolina rallied in the second half, cutting the deficit to 35-23, but Wilson threw his fifth touchdown of the day, this time a 47-yarder to Mellette, to seal the win.
Eddie Sullivan led Western Carolina with 168 yards on 12-of-22 passing and added 76 yards rushing.
Elon has won the last six games in the series, scoring at least 26 points in each of those meetings.
Corey Robinson is returning for his senior year on the gridiron at Notre Dame while also assuming the responsibilities of student-body president.
Baylor will hire more counselors and provide additional training for faculty in an effort to improve the school's response to sexual assault incidents, school regents said Friday.
Answering questions about the hype around two young quarterbacks, whether Stanford will sooner or later fall back into mediocrity and more.
FOX Sports' Clay Travis joins The Paul Finebaum Show to discuss the possibility of losing Tigers football to budget cuts.
The Naismith Memorial Basketball Hall of Fame announced 14 finalists for the Class of 2016 on Friday, including Allen Iverson, Tom Izzo, Shaquille O'Neal and Yao Ming.
Discussing the transfer of Barry J. Sanders to Oklahoma State, what the latest staff movement means for Charlie Strong and TCU's linebacking corps.
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