Wilson, who finished with 378 yards passing, tallied his fourth consecutive 300-yard passing game while Mellette had more than 100 receiving yards for the 18th time in his career.
Elon led 28-0 at halftime behind three passing touchdowns from Wilson, including two to Mellette, and a 48-yard run from Tracey Coppedge.
Western Carolina rallied in the second half, cutting the deficit to 35-23, but Wilson threw his fifth touchdown of the day, this time a 47-yarder to Mellette, to seal the win.
Eddie Sullivan led Western Carolina with 168 yards on 12-of-22 passing and added 76 yards rushing.
Elon has won the last six games in the series, scoring at least 26 points in each of those meetings.
New Mexico State Coach Doug Martin Halftime Interview
Brian Hill rushed for 232 yards and a touchdown, setting a school record for rushing yards in a season, and Cameron Coffman tossed three touchdown passes as Wyoming beat UNLV 35-28 Saturday.
Lumi Kaba 41 yd FG GOOD
Kyle Shurmur pass complete to Caleb Scott for 25 yds to the Tenn 40 for a 1ST down
Connor Cook pass complete to Aaron Burbridge for 29 yds for a TD
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